Phosphodiesterase-5 Inhibitors (PDE5Is) in Help of Men with Erectile Dysfunction (ED)
What are the Phosphodiesterase 5 inhibitors (PDE5Is)? You will see these a lot in the topic of ED. When it comes toED treatment, PDE5Is have a privileged place and role among all recommended options as FDA approved medicinal products.
These orally administered drugs can alleviate the conditions in penile blood vessels, which may affect the inability to achieve erection. In particular, by blocking the enzyme phosphodiesterase-5 (PDE5) they stop it from breaking down the erection-producing chemical cyclic guanosine monophosphate (cGMP). Increasing cGMP enables the penis to fill with blood and to stay firm and erect long enough for sexual intercourse by relaxing the smooth muscles surrounding blood vessels, and dilating them so that blood can flow into penis in abundance. This is the most critical stage of the erection process assisted by PDE5Is. To procure the erection, you will need sexual arousal or stimulation at all times to make these drugs work properly.
There are mainly four FDA approved PDE5Is: Sildenafil, Vardenafil, Tadalafil, and Avanafil. The PDE5Is are the most preferred drugs in widespread use to provide support for people with ED. Many doctors prioritize this kind of medical treatment for their patients.
The PDE5Is can be a good way to treat ED. Your doctor may suggest the most appropriate drug for you based on the diagnosis of your specific condition. This will depend on your condition, your sexual activity level or expectations, and your overall health conditions including concomitant health problems you may have. Because of the high success rate of these drugs, there are many fake pills claiming to contain PDE5I sold on the market, and many herbal or traditional ED medications intentionally contaminated with PDE5Is under the counter were identified by regulatory health authorities. Most of them are dangerous to take, and may be ineffective or detrimental to your health due to lack of appropriate dosing and purity of the active pharmaceuticals. It is important to only get the drugs prescribed by your your trusted doctor and purchased from official pharmacies in your area. Your doctor will recommend the type and dosage of the drugs with different characteristics as well as the frequency of taking the pill depending on your specific needs and the existence of concomitant medications and health problems including benign prostate hyperplasia (BPH).
It might be surprising for you to know that Sildenafil is actually one of the PDE5Is. The branded products manufactured using this PDE5I have been widely used by people for decades. It is still one of the most prominent pills sold on earth. Your doctor shall adjust the dosage based on your needs.
Meanwhile, Tadalafil is also one of the most popular. Again, the dosage will be adjusted according your needs. You will need to discuss this medication with your doctor.
Vardenafil comes in two forms: pill and dissolvable tablet. Your doctor will suggest the appropriate dosage and frequency of taking based on your needs.
The Avanafil is the newest amongst the 4 types of PDE5Is. Taking the pill with food can delay the effects of the drugs. You should closely follow your doctor’s recommendations including the timing and intervals of the dose as well as taking it either on empty stomache or not.
All of the drugs are effective in treating ED. However, you will need to consult with your doctor first, since you may not know the side effects of and food or drug interactions by using them for a long time. PDE5Is can cause heartburn, stuffy nose, dizziness, headache and sometimes nausea. It is important to check your condition with your doctor. That is where you will get the best advice for dealing with your ED problems and keeping away from intolerable side effects of medications.In any case, you will always profit from benefits of consulting your decisions with your doctor.